Detalhe da pesquisa
1.
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
N Engl J Med
; 389(8): 722-732, 2023 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37611122
2.
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
J Infect Dis
; 225(4): 696-704, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34460932
3.
Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates.
Antimicrob Agents Chemother
; 66(4): e0143721, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35266828
4.
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Antimicrob Agents Chemother
; 66(10): e0081722, 2022 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36094216
5.
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
Antimicrob Agents Chemother
; 65(10): e0077121, 2021 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34339273
6.
Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.
Malar J
; 20(1): 292, 2021 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-34193148
7.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
Proc Natl Acad Sci U S A
; 115(29): E6863-E6870, 2018 07 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29967165
8.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33433953
9.
Changing Antimalarial Drug Sensitivities in Uganda.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28923866
10.
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.
J Med Chem
; 67(2): 1460-1480, 2024 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38214254
11.
Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites.
Antimicrob Agents Chemother
; 57(9): 4245-4251, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23796921
12.
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Microbiol Spectr
; 11(3): e0523622, 2023 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37158739
13.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome InhibitorsâPart II.
J Med Chem
; 66(2): 1484-1508, 2023 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36630286
14.
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
Nat Commun
; 13(1): 6353, 2022 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36289202
15.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Nat Commun
; 13(1): 2158, 2022 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35444200
16.
Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study.
Lancet Microbe
; 2(9): e441-e449, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34553183
17.
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
J Med Chem
; 64(9): 6085-6136, 2021 05 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33876936
18.
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase.
ACS Infect Dis
; 6(11): 2994-3003, 2020 11 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32970404
19.
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
Nat Commun
; 11(1): 2107, 2020 04 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32355199
20.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 63(11): 6179-6202, 2020 06 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32390431